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THE EXPRESSIONS OF CD44v6 AND PTEN IN COLORECTAL CARCINOMA AND THEIR RELATIONSHIP WITH ITS INFILTRATION AND METASTASIS
Author(s): 
Pages: 3-5
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  结直肠肿瘤肿瘤转移CD44v6PTEN免疫组织化学;
Abstract: 目的 探讨CD44v6和PTEN蛋白表达与结直肠癌浸润和转移的关系.方法 应用免疫组织化学技术,检测90例结直肠癌、20例结直肠腺瘤和20例正常结直肠黏膜组织中的CD44v6和PTEN蛋白表达.结果 90例结直肠癌组织中CD44v6和PTEN蛋白阳性表达率分别为75.6%和46.7%.结直肠癌组织中CD44v6表达阳性率显著高于结直肠腺瘤和正常结直肠黏膜组织(χ2=27.60、35.22,P<0.05),而PTEN表达阳性率显著低于结直肠腺瘤和正常结直肠黏膜组织(χ2=16.08,P<0.05).CD44v6和PTEN表达与结直肠癌的浆膜浸润、淋巴结转移和肝脏转移相关(χ2=4.59~13.60,P<0.05).结直肠癌组织中CD44v6与PTEN表达呈负相关(χ2=14.46,P<0.05).结论 CD44v6和PTEN表达与结直肠癌浸润转移密切相关,检测CD44v6和PTEN蛋白表达可作为判断结直肠癌预后的客观指标.
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