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SIGNIFICANCE OF VEGF-C AND VEGFR-3 EXPRESSION ON LYMPHANGIOGENESIS AND LYMPH-NODE METASTASIS IN NON-SMALL CELL LUNG CANCER
Author(s): 
Pages: 6-7,10
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  非小细胞肺血管内皮生长因子C血管内皮生长因子受体3淋巴管生成淋巴转移;
Abstract: 目的 探讨非小细胞肺癌组织血管内皮生长因子C(VEGF-C)及VEGF受体3(VEGFR-3)表达对淋巴管生成和淋巴转移意义.方法 用免疫组化方法检测62例非小细胞肺癌组织VEGF-C和VEGFR-3的表达情况.结果 非小细胞肺癌组织中,VEGF-C阳性表达率为77.4%,有淋巴结转移组VEGF-C阳性表达率显著高于无淋巴结转移组(χ2=7.33,P<0.05 ).VEGFR-3阳性表达率为74.4%,淋巴结转移组VEGFR-3阳性微淋巴管数量明显多于无淋巴结转移组(t=11.18,P<0.05).VEGF-C表达强度越高,VEGFR-3阳性微淋巴管数量越多,二者呈正相关(r=0.912,P<0.05).结论 非小细胞肺癌组织中VEGF-C的表达与VEGFR-3阳性微淋巴管数量和淋巴结转移有关.
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