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A STUDY OF ras GENE MUTATION IN EPSTEIN-BARR VIRUS-ASSOCIATED GASTRIC CARCINOMA
Author(s): 
Pages: 21-23
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  胃肿瘤疱疹病毒4型基因ras;
Abstract: 目的 探讨EBV感染、ras基因突变在EBV相关胃癌(EBVaGC)发生发展中的作用.方法 应用PCR-RFLP技术,分别检测13例EBVaGCs、45例与之匹配的EBV阴性胃癌(EBVnGC)以及58例相应癌旁组织中H-ras 12位点,K-ras 12、13位点突变情况.结果 检测到2例H-ras 12位点突变,突变率为4.44%(2/58),均发生在EBVnGC组织.结论 胃癌组织 ras 基因突变率较低,ras基因突变与EBVaGC的发生无明显相关性.
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