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THE EFFECT OF PREOPERATIVE RADIOTHERAPY ON DNA CONTENT IN RECTAL CARCINOMA AND ITS PROGNOSIS
Author(s): 
Pages: 27-28
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  直肠肿瘤放射疗法计算机辅助DNA;
Abstract: 目的 研究术前放疗对直肠癌DNA含量及其预后的影响.方法 将60例直肠癌 DUKES分期 B、C 期病人, 随机分成两组.治疗组29例采用术前放疗+手术+术后放疗治疗;对照组31例采用手术+术后放疗治疗,采用 ICM 图像分析技术检测两组 DNA含量,并进行随访.结果 治疗组中2倍体肿瘤8例,对照组中未见2倍体.治疗组的DNA指数低于对照组,差异有显著性(t=2.66,P<0.01). 治疗组5倍体超过率明显低于对照组(P<0.01).治疗组5年生存率62.07%,对照组41.94%,两组比较,差异无显著性(χ2=2.43,P>0.05).结论 术前放疗降低了直肠癌细胞中的DNA含量,改善了病人的预后,在直肠癌的治疗中具有重要价值.
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