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THE LEVELS OF LEPTIN AND INSULIN IN PRE-ECLAMPSIA PATIENTS AND THEIR RELATIONSHIP WITH FETAL GROWTH AND DEVELOPMENT
Author(s): 
Pages: 35-36,40
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  子痫妊娠瘦素胰岛素婴儿新生出生体质量;
Abstract: 目的 了解子痫前期病人及其新生儿瘦素、胰岛素水平,探讨瘦素、胰岛素在子痫前期发病中的意义及其与胎儿宫内生长发育的关系.方法 采用放射免疫分析法,对30例子痫前期病人(其中轻度、重度各15例)及30例正常孕妇的血清瘦素、胰岛素水平进行测定,同时测定其新生儿脐血瘦素、胰岛素水平.结果 子痫前期病人及新生儿脐血血清瘦素及胰岛素水平明显高于对照组(F=9.048~67.360,q=2.595~16.061,P<0.05、0.01);重度子痫前期病人血清瘦素与胰岛素水平呈正相关(r=0.661,P<0.01);重度子痫前期病人新生儿体质量明显低于正常对照组,差异有统计学意义(F=23.705,q=2.434~5.998,P<0.01);各组新生儿瘦素水平与体质量呈正相关(r=0.423~0.757,P<0.05、0.01).结论 子痫前期病人血清瘦素及胰岛素水平有随病情加重逐渐增高的趋势,两者共同参与子痫前期的发病.脐血瘦素水平可以反映胎儿宫内发育情况.
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