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COMBINED DETECTION OF HEPATITIS B VIRUS Pre-S2-Ag, HBcAb-IgM AND HEPATITIS B VIRUS FIVE MARKINGS
Author(s): 
Pages: 56-58
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  肝炎病毒乙型前S2抗原病毒核心蛋白质类实验室技术和方法;
Abstract: 目的 探讨乙肝病毒前S2抗原(PreS2-Ag)、乙肝病毒核心抗体IgM(HBcAb-IgM)与乙肝五项指标联合检测的临床意义.方法 采用ELISA法对618例标本进行乙肝五项指标和PreS2-Ag及HBcAb-IgM检测.结果 乙肝五项指标中HBeAg阳性率最低(3.56%),HBsAg阳性率较高(8.25%),HBcAb阳性率最高(43.37%).PreS2-Ag的阳性率(6.63%)高于HBeAg而低于HBsAg.在HBsAg阳性组中,PreS2-Ag阳性率为80.39%,HBsAg阴性组中无1例PreS2-Ag阳性.PreS2-Ag在"大三阳"组中阳性率为90.91%(10/11),在"小三阳"组中阳性率为95.23%(20/21),在"双阳"组(HBsAg、HBcAb阳性)中阳性率为58.33%(7/12).HBcAb-IgM的阳性率较低(0.49%).结论 PreS2-Ag比HBeAg更敏感地反映了病毒的复制情况,PreS2-Ag、HBcAb-IgM与乙肝五项指标联合检测并利用s/co值能更好地对HBV感染者进行临床分析.
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