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EFFECTS OF RHIZOMA PICRORHIZAE ON NERVE GROWTH FACTOR IN RAT BRAIN FOLLOWING CEREBRAL ISCHEMIA
Author(s): 
Pages: 69-71
Year: Issue:  1
Journal: ACTA ACADEMIAE MEDICAL QINGDAO UNIVERSITATIS

Keyword:  胡黄连中草药再灌注损伤神经生长因子;
Abstract: 目的 观察大鼠脑缺血再灌注损伤后脑组织神经生长因子(NGF)的变化,探讨胡黄连抗脑缺血再灌注损伤的机制.方法 参照线栓法制作脑缺血再灌注模型,免疫组织化学方法观察胡黄连对脑皮质、纹状体NGF表达的影响.结果 手术组缺血侧皮质区和纹状体区于缺血再灌注1 d时NGF表达至高峰,3 d后逐渐下降,14 d降至基础水平;胡黄连治疗组大鼠脑皮质与纹状体的NGF阳性细胞显著增加, 与假手术组及模型组相比差异有显著性(F=4.8、9.1,q=13.6~17.2;t=12.6~18.4,P<0.05).结论 胡黄连可使脑缺血再灌注损伤后脑组织内NGF表达增加.
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