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The efficacy and safety of methyclothiazide tablets in treatment of patients with mild-to-moderate essential hypertension
Author(s): 
Pages: 35-37
Year: Issue:  1
Journal: PHARMACEUTICAL CARE AND RESEARCH

Keyword:  高血压药物疗法甲氯噻嗪;
Abstract: 目的:观察甲氯噻嗪片治疗轻、中度原发性高血压的降压效果和安全性.方法:门诊轻、中度原发性高血压病人,随机分为甲氯噻嗪组和氢氯噻嗪组,每组各24例,分别服甲氯噻嗪2.5 mg或氢氯噻嗪25 mg,qd,治疗4周后舒张压≥90 mmHg者剂量加倍,疗程8周.服药后每2周随访1次,测定血压和心率.治疗前后测定血、尿常规,血生化指标及心电图,并监测血钾,必要时口服补钾.结果:服药第2、4、6、8周末两组血压均较治疗前降低(P<0.01),治疗8周后与治疗前比较,甲氯噻嗪组和氢氯噻嗪组收缩压/舒张压(SBP/DBP)分别下降(16.0±7.9)/(15.7±5.2)mmHg和(17.2±6.4)/(16.2±5.0)mmHg;组间下降值无统计学差异;降压总有效率分别为87.5%和83.3%(P>0.05).两组治疗前后心率均无明显变化,不良反应轻微,出现较多的是头痛、头晕.甲氯噻嗪组和氢氯噻嗪组分别于用药4周后出现低血钾2例和1例,补钾后恢复正常.其余实验室指标无明显改变.结论:甲氯噻嗪片治疗轻、中度原发性高血压安全、有效.
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