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Photocytotoxic Effect of Hypericin Extract from Hypericum Performatum L. on MDA231 Human Mammary Carcinoma Cell Lines in vitro
Author(s): 
Pages: 1-4
Year: Issue:  1
Journal: THE CHINESE JOURNAL OF MODERN APPLIED PHARMACY

Keyword:  金丝桃素金丝桃素提取物光动力治疗乳腺癌;
Abstract: 目的 研究贯叶金丝桃中金丝桃素(HY)提取物对人乳腺癌细胞株MDA231的体外光动力杀伤效应.方法 通过测定胞内荧光强度来确定细胞对金丝桃素的吸收,用显微镜观察、MTT法和DNA电泳分析法来研究金丝桃素对细胞的生长抑制作用.结果 光活化的金丝桃素对MDA231细胞有显著的体外杀伤效应,其抑制细胞生长的能力与HY的浓度及光照能量密切相关.结论 金丝桃素提取物在光照下能明显抑制乳腺癌细胞的生长,金丝桃素用于治疗乳腺癌具有广阔的开发应用前景.
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