The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
GPI-1046 stimulates chicken dorsal root ganglion neurite outgrowth in the presence of nerve growth factor at low concentration in vitro
Author(s): 
Pages: 791-795
Year: Issue:  6
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  GPI-1046nerve growth factorimmunophilinneurite outgrowthchicken dorsal root ganglia;
Abstract: The purpose of this investigation was to re-evaluate the neurotrophic effect of GPI-1046 on neurite outgrowth in vitro.GPI-1046 was synthesized and identified with mass spectrometry,nuclear magnetic resonance and elemental analysis.Chicken dorsal root ganglions(DRGs) were removed and divided into three groups:(1)The DRGs were cultured in DMEM containing different concentrations of GPI-1046;(2)The DRGs were cultured in DMEM containing nerve growth factor (NGF)alone at 0.8 and 8 ng/mL,respectively;(3)The DRGs were cultured in DMEM containing both different concentrations of GPI-1046 and NGF at 0.8ng/mL.The results showed that GPI-1046 alone could not stimulate chicken DRG neurite outgrowth;however,GPI-1046 stimulated DRG neurite outgrowth only in the presence of NGF at low concentration in the culture medium.
Related Articles
No related articles found