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Relationship between GATA-3 and IL-12 in patients with allergic rhinitis
Author(s): 
Pages: 1087-1089
Year: Issue:  23
Journal: JOURNAL OF CLINICAL OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY

Keyword:  鼻炎变应性GATA-3白细胞介素12;
Abstract: 目的:探讨变应性鼻炎患者转录因子GATA-3和IL-12的表达及关系.方法:通过RT-PCR和ELISA检测37例变应性鼻炎患者和12例对照鼻黏膜组织中GATA-3和IL-12的表达.结果:PCR反应后变应性鼻炎患者和对照鼻黏膜组织中GATA-3相对密度分别为0.579±0.102和0.128±0.021;IL-12的含量分别为(53.7±12.3)ng/g和(121.9±20.4)ng/g;GATA-3与IL-12的表达呈负相关关系(r=-0.932 4,P<0.05).结论:变应性鼻炎患者鼻黏膜GATA-3表达增高与IL-12的异常表达有关.恢复或提高局部组织IL-12的表达,能抑制GATA-3表达的增高,改善变应性鼻炎的症状.
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