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Changes of Levels of Serum Intereferon - γ and Interleukin - 4 in Children with Mycoplasma Pneumoniae Encephalitis
Author(s): 
Pages: 1257-1258
Year: Issue:  16
Journal: JOURNAL OF APPLIED CLINICAL PEDIATRICS

Keyword:  肺炎支原体脑炎干扰素-γ白细胞介素-4;
Abstract: 目的 探讨肺炎支原体(MP)脑炎患儿急性期血清干扰素-γ(IFN-γ)和IL-4水平变化及其意义.方法 采用酶联免疫吸附(ELISA)双抗体夹心法检测MP脑炎24例急性期和24例健康儿童外周血血清IFN-γ和IL-4水平,并对确诊的MP脑炎患儿予阿奇霉素静脉滴注,10例同时应用地塞米松,15例应用丙种球蛋白治疗.结果 健康对照组血清IFN-γ、IL-4为(85.35±6.91)、(26.78±9.89)ng/L;MP脑炎组IFN-γ、IL-4为(98.56±12.93)、(45.55±17.58)ng/L.MP脑炎组患儿IFN-γ、IL-4水平均较健康对照组升高,差异有显著性(Pa<0.05).结论 MP脑炎患儿血清INF-γ、IL-4均升高,提示MP脑炎发病可能与免疫功能紊乱相关,且可引起继发性免疫功能低下.
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