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Effects of Asiaticoside Ointment on Experimental Skin Pigmentation in Guinea Pigs
Author(s): 
Pages: 526-531
Year: Issue:  9
Journal: WORLD CLINICAL DRUGS

Keyword:  积雪苷霜软膏色素沉着黑色素细胞酪氨酸超氧化物歧化酶;
Abstract: 目的 研究积雪苷霜软膏对皮肤色素沉着的抑制作用,为其治疗色素沉着性疾病提供实验依据.方法 中波紫外线(UVB)照射豚鼠以形成皮肤色素沉着模型.造模第30日后将模型鼠分为模型组及积雪苷霜组.模型组给予赋形剂,积雪苷霜组每日涂积雪苷霜软膏,连续30日,检测皮肤组织酪氨酸(Tyr)、超氧化物歧化酶(SOD)、丙二醛(MDA)含量的变化,并运用ElivisionTMplus免疫组化法和图像分析法观测黑色素细胞在表皮中的分布及其分泌功能.结果 模型组表皮黑色素沉着增加,Tyr、MDA含量明显升高,SOD含量降低.积雪苷霜组能减轻模型豚鼠表皮黑色素沉着,显著降低Tyr、MDA水平,升高SOD水平.结论 积雪苷霜软膏对UVB诱导的豚鼠皮肤色素沉着有一定的抑制作用.
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