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Interleukin-18 and liver cancer
Author(s): 
Pages: 519-521
Year: Issue:  7
Journal: JOURNAL OF INTERNATIONAL ONCOLOGY

Keyword:  肝肿瘤白细胞介素18细胞因子类;
Abstract: 白细胞介素18(IL-18)位于11q22.2-q22.3染色体上,其前体形式由193个氨基酸残基组成,被称为干扰素(IFN)γ诱生因子,它作为一种新近发现的致炎细胞因子近年来备受关注,其与肿瘤的相关性研究令人鼓舞.在肝癌研究中,初步发现IL-18可通过激活机体T细胞及自然杀伤细胞,有效抑制肝癌细胞增殖,并激活机体免疫功能,杀伤癌细胞.另外在疫苗研制方面IL-18也有潜在的临床应用价值.
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