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Analysis of HPV genotypes in paraffin-embedded tissue of cervical cancer
Author(s): 
Pages: 299-300,294
Year: Issue:  4
Journal: JIANGXI JOURNAL OF MEDICAL LABORATORY SCIENCES

Keyword:  人乳头瘤病毒基因型基因芯片宫颈癌;
Abstract: 目的 调查本地区子宫颈癌病理组织中HPV基因型别,为子宫颈癌HPV筛查方法的选择提供依据.方法 应用可检测23种HPV基因型别的基因芯片法对61例经病理证实的子宫颈癌石蜡包埋组织进行HPV基因型别分析.结果 在61例子宫颈癌组织标本中,共检出41例HPV阳性,阳性率为67.2%,其中HPV16型别26例,占HPV阳性病例的63.4%(26/41),HPV18型别12例,占HPV阳性病例的29.2%(12/41),HPV33型1例,不同基因型混合感染2例,分别为HPV16/18与HPV16/59型别混合感染各一例,各占HPV阳性病例的2.4%(1/41).结论 在本地区的61例子宫颈癌病理组织中,以16和18基因型最为常见,共占HPV阳性型别构成比的95.3%,说明本地区与子宫颈癌密切相关的HPV基因型别较为集中.
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