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Relationship between low ankle-brachial index and mortality of men with several atherosclerotic risk factors: a cohort study of 1941 cases
Author(s): LI Xian-kai, LI Jue, XING Yan, BUAIJIAER Hasimu, YU Jin-ming, LUO Ying-yi, ZHENG Li-qiang, HU Da-yi
Pages: 960-
963
Year: 2007
Issue:
14
Journal: NATIONAL MEDICAL JOURNAL OF CHINA
Keyword: 动脉硬化; 踝臂指数; 病死率; 危险因素;
Abstract: 目的 研究具有多重动脉硬化危险的男性的踝臂指数(ABI)与全因和心血管疾病(CVD)病死率的关系.方法 多中心连续入选内科住院病人中具有多个动脉硬化危险因素的男性病人1941例,年龄36~96岁,进行基线特征调查并平均随访13个月,观察其终点事件的发生率.结果 外周动脉疾病(PAD)组的全因病死率(15.4%vs 7.7%)和CVD病死率(5.1%vs 1.8%)均高于正常组,且差异有统计学意义.在重度PAD组、轻度至中度PAD组、临界组和正常对照组中的全因病死率(分别为17.6%,15.2%,10.1%和7.3%)和CVD病死率(分别为14.7%,4.4%,2.9%和1.6%)差异有显著统计学意义(P<0.001).经Cox回归分析后,轻至中度PAD组(0.4<ABI≤0.9)全因死亡的RR为1.585(95%CI:1.126~2.230).重度PAD组(ABI≤0.4)CVD死亡的RR为4.443(95%CI:1.811~10.902),轻至中度PAD组CVD死亡的RR为1.859(95%CI:1.091~3.166).PAD组的全因死亡和CVD死亡生存明显低于正常组.结论 ABI是全因死亡和CVD死亡的独立危险因素,ABI越低CVD病死率可能越高.
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