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Frequency Response of Transmenbrane Potential on Cell Inner and Outer Membrane Based on Equivalent Circuit Model
Author(s): 
Pages: 6-11
Year: Issue:  6
Journal: TRANSACTIONS OF CHINA ELECTROTECHNICAL SOCIETY

Keyword:  细胞等效电路模型跨膜电位频率响应指数衰减陡脉冲;
Abstract: 提出一种适用于高频范围分析的细胞等效电路模型,给出了细胞内外膜跨膜电位的计算公式,对其频率响应进行仿真分析表明,细胞外膜跨膜电位频率响应可视为一阶低通滤波器,而内膜跨膜电位频率响应可视为一阶带通滤波器.应用指数衰减陡脉冲对人卵巢腺癌SKOV3细胞进行处理,实验结果和频谱分析表明,指数衰减陡脉冲的下降沿和上升沿分别包含了大量的低频和高频分量,分别作用于肿瘤细胞的外膜和内膜,从而对整个肿瘤细胞产生普遍的杀伤作用.
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