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Effects of cholecystokinin and secretin on pancreatic duct pressure and pancreatic blood flow in Australian brush-tailed possums
Author(s): 
Pages: 638-640
Year: Issue:  6
Journal: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Keyword:  缩胆囊素胰泌素胰管压力胰腺血流量负鼠;
Abstract: 目的:观察缩胆囊素和胰泌素对胰管压力及胰腺血流量的影响,以探讨急性胆源性胰腺炎的发病机制.方法:6只负鼠静脉灌注缩胆囊素和胰泌素5 μg/kg,分别胰管插管,并连接到压力感受器上测定胰管压力,激光多普勒测定胰腺血流量.结果:在注射缩胆囊素和胰泌素后5 min,胰管压力分别由16.2±1.8 mmHg和16.8±1.7mmHg上升到18.9±2.1 mmHg和25.6±1.9mmHg,在随后的5-15 min期间,胰管压力在此水平缓慢的下降并维持在较高的水平,分别为17.6±2.4 mmHg和21.5±2.5 mmHg(P<0.002和P<0.001);胰腺血流量分别由0.58±0.09mL/100g和0.55±0.04 mL/100g上升到0.75±0.11mL/100g和0.85±0.12 mL/100 g,在随后的5-15 min期间,随着胰管压力上升,胰腺血流量反而缓慢的下降并维持在较低的水平,分别为0.51±0.09 mL/100 g和0.39±0.11 mL/100 g(P<0.001),与缩胆囊素相比,胰泌素的这种作用更为明显(P<0.05).结论:缩胆囊素和胰泌素可增加胰管压力,并使胰腺血流量在开始增加,增加的胰管压力反而使胰腺血流量下降,提示在胰管有梗阻的情况下,这两种激素可能是急性胆源性胰腺炎发生并发展的重要始动因素之一.
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