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Issue:
Expression of tissue factor antigen in different kinds of human cancer
Author(s):
XIANG Gui-ming
,
SU Yong-ping
,
CHENG Tian-min
,
AI Guo-ping
Pages:
425
-
427
Year:
2007
Issue:
6
Journal:
CHINESE JOURNAL OF CANCER PREVENTION AND TREATMENT
Keyword:
凝血致活酶
;
肿瘤
;
免疫组织化学
;
Abstract:
目的:研究组织因子(tissue factor,TF)在各种类型癌组织中的表达和作为癌症治疗靶点的可行性.方法:采用免疫组化法检测了110例患者癌组织中的TF.结果:在绝大多数受检的癌组织中都能够检测到TF的表达,阳性率92.8%(102/110),且以强阳性(+++)居多,不同亚型的23例结直肠癌、19例肺癌和18例肝癌的肿瘤细胞和肿瘤血管内皮细胞表面均有TF的特异性高表达,但是正常血管内皮细胞表面不表达TF.结论:TF可以作为靶向抗癌研究的一个新"靶点".
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