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Expression of tissue factor antigen in different kinds of human cancer
Author(s): 
Pages: 425-427
Year: Issue:  6
Journal: CHINESE JOURNAL OF CANCER PREVENTION AND TREATMENT

Keyword:  凝血致活酶肿瘤免疫组织化学;
Abstract: 目的:研究组织因子(tissue factor,TF)在各种类型癌组织中的表达和作为癌症治疗靶点的可行性.方法:采用免疫组化法检测了110例患者癌组织中的TF.结果:在绝大多数受检的癌组织中都能够检测到TF的表达,阳性率92.8%(102/110),且以强阳性(+++)居多,不同亚型的23例结直肠癌、19例肺癌和18例肝癌的肿瘤细胞和肿瘤血管内皮细胞表面均有TF的特异性高表达,但是正常血管内皮细胞表面不表达TF.结论:TF可以作为靶向抗癌研究的一个新"靶点".
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