Clinical Application of Proton Magnetic Resonance Spectroscopy in Children with Febrile Seizure
Author(s): SHAO Xiao-li, ZHOU Zhong-shu, HONG Wen, SHEN Ming, YANG Ling, WANG Yun-feng
Pages: 373-374,380
Year: 2007 Issue: 5
Journal: JOURNAL OF APPLIED CLINICAL PEDIATRICS
Keyword: 热性惊厥; 氢质子磁共振波谱; 脑损伤;
Abstract: 目的 应用氢质子磁共振波谱(1H-MRS)检测热性惊厥(FS)患儿脑组织生化代谢物,了解FS发作后脑损伤情况,探讨1H-MRS在FS中应用的意义.方法 对25例FS患儿和6例神经系统正常儿童进行常规头颅MRI和颞叶海马区的1H-MRS检查.25例FS患儿中,15例为单纯性热性惊厥(SFS),10例为复杂性热性惊厥(CFS).检测指标为N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、谷氨酸-谷氨酰胺复合物(Glx)和乳酸(Lac)的信号强度,计算并比较NAA/(Cho+Cr)和Lac/Cr的比值.结果 头颅MRI检查结果为FS组及对照组均未显示异常.1H-MRS检测结果为NAA/(Cho + Cr)比值,SFS组为0.71±0.05,CFS组为0.65±0.04,对照组为0.73±0.05,CFS组明显低于SFS组及对照组(Pa＜0.01),但后二者之间无明显差异(P＞0.05).Lac/Cr比值SFS组(0.32±0.21)和CFS组(0.63±0.30)高于对照组(0.05±0.04)(Pa＜0.05),且CFS组高于SFS组(P＜0.01).结论 1H-MRS作为一项无创检查,能更敏感地发现FS患儿的早期脑损伤,为FS尤其是CFS患儿的治疗、评估预后提供客观依据.
Pages: 373-374,380
Year: 2007 Issue: 5
Journal: JOURNAL OF APPLIED CLINICAL PEDIATRICS
Keyword: 热性惊厥; 氢质子磁共振波谱; 脑损伤;
Abstract: 目的 应用氢质子磁共振波谱(1H-MRS)检测热性惊厥(FS)患儿脑组织生化代谢物,了解FS发作后脑损伤情况,探讨1H-MRS在FS中应用的意义.方法 对25例FS患儿和6例神经系统正常儿童进行常规头颅MRI和颞叶海马区的1H-MRS检查.25例FS患儿中,15例为单纯性热性惊厥(SFS),10例为复杂性热性惊厥(CFS).检测指标为N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、谷氨酸-谷氨酰胺复合物(Glx)和乳酸(Lac)的信号强度,计算并比较NAA/(Cho+Cr)和Lac/Cr的比值.结果 头颅MRI检查结果为FS组及对照组均未显示异常.1H-MRS检测结果为NAA/(Cho + Cr)比值,SFS组为0.71±0.05,CFS组为0.65±0.04,对照组为0.73±0.05,CFS组明显低于SFS组及对照组(Pa＜0.01),但后二者之间无明显差异(P＞0.05).Lac/Cr比值SFS组(0.32±0.21)和CFS组(0.63±0.30)高于对照组(0.05±0.04)(Pa＜0.05),且CFS组高于SFS组(P＜0.01).结论 1H-MRS作为一项无创检查,能更敏感地发现FS患儿的早期脑损伤,为FS尤其是CFS患儿的治疗、评估预后提供客观依据.
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