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The frequency of CD4+ CD25+ Foxp3+ regulatory T cells correlates to the disease progression of HIV-1 infection in Chinese
Author(s): 
Pages: 278-281
Year: Issue:  3
Journal: CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY

Keyword:  HIV-1调节性T细胞Foxp3活化凋亡;
Abstract: 目的 对中国HIV-1感染者CD4+CD25+Foxp3+调节性T细胞水平及与疾病进展相关性进行研究,探讨CD4+CD25+Foxp3+调节性T细胞在HIV-1疾病进程中发挥的作用.方法 选取35名HIV-1感染者及14名健康对照,应用流式细胞仪胞内染色技术在单细胞水平检测CD4+CD25+Foxp3+调节性T细胞表达及淋巴细胞活化、凋亡水平.结果 中国HIV-1感染者CD4+CD25+Foxp3+T细胞水平与CD4+T细胞显著负相关(r=-0.544,P=0.001),与病毒载量明显正相关(r=0.484,P=0.026),与CD4+T细胞凋亡(CD95表达)水平明显正相关(r=0.431,P=0.011).艾滋病人CD4+CD25+Foxp3+T细胞水平明显高于无症状HIV感染者(P<0.05),与健康人相比差异无统计学意义.艾滋病人CD4+、CD8+T细胞凋亡水平明显高于无症状HIV感染者及健康人(P<0.05),艾滋病人及无症状HIV感染者CD4+、CD8+T细胞活化明显高于健康人(P<0.05).结论 中国HIV-1感染者CD4+CD25+Foxp3+调节性T细胞水平与疾病进展明显相关.
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