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Serum uric acid and lipids level and its treatment early by irbesartan in male spontaneously hypertensive rats
Author(s): 
Pages: 136-137,144
Year: Issue:  2
Journal: CHINESE JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE

Keyword:  血管紧张素Ⅱ(1型)受体拮抗剂尿酸高脂血症动脉硬化大鼠近交自发性高血压;
Abstract: 目的:探讨早期雄性自发性高血压大鼠(SHR)血清尿酸(UA)和血脂代谢异常在高血压靶器官损害进程中的作用,并观察厄贝沙坦(irbesartan)对血尿酸和血脂代谢的影响.方法:对象为15周龄雄性SHR 20只和正常雄性同龄Wistar Kyoto(WKY)大鼠10只.将SHR随机分为两组:厄贝沙坦治疗组(按厄贝沙坦50mg/kg·d从饮水给药);SHR阳性对照组.后者与WKY正常对照组喂以等量蒸馏水代替.实验于三个月后停药,测体重和血压,检测血清UA、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)值.结果:实验三个月后,与WKY组比较,SHR组UA水平显著增高(P<0.05),血压和TG水平显著增高(P<0.01);与SHR组比较,厄贝沙坦组血压和TG水平显著降低(P<0.01),UA水平显著降低(P<0.05).结论:高血压病早期已经存在着高尿酸血症和血脂异常等代谢异常的临床征象,厄贝沙坦既具有降低TG又具有降低UA的作用,可能有抗动脉粥样硬化和肾保护作用.
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