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Effects of hyperthermia combined with chemotherapy on the absolute counts of lymphocyte in postoperative patients with lung cancer
Author(s): 
Pages: 17-19
Year: Issue:  1
Journal: CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY

Keyword:  肺肿瘤淋巴细胞高温诱发化学疗法辅助;
Abstract: 目的 分析热化疗对肺癌术后的近期疗效及其对患者外周血淋巴细胞绝对数值的影响.方法 采用流式细胞术检测36例肺癌术后患者热化疗前后外周血淋巴细胞绝对数值,并与正常对照作比较.结果 患者热化疗前后淋巴细胞绝对数值均低于正常对照值(P<0.05).热化疗有效者总T细胞(CD3+)、辅助T淋巴细胞(CD3+CD4+)、NK细胞(CD16+CD56+)均显著升高(P<0.05),抑制T淋巴细胞(CD3+CD8+)降低但差异无统计学意义(P>0.05),B细胞(CD19+)变化不显著(P>0.05).热化疗无效者CD3+、CD3+CD4+、CD16+CD56+显著降低(P<0.05),而CD3+CD8+、CD19+变化不明显(P>0.05).结论 肺癌患者免疫功能低下,有效热化疗能提高患者的淋巴细胞免疫功能.临床上对患者外周血淋巴细胞绝对数值的观察,有助于对患者的治疗进行监测.
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