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Distribution of interstitial cells of Cajal and synaptophysin in the Hirschsprung disease bowel
Author(s): 
Pages: 2351-2353
Year: Issue:  20
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  Hirschsprung病突触免疫组织化学Cajal间质细胞;
Abstract: 目的:探讨Cajal间质细胞(ICCs)及突触素(SY)在先天性巨结肠发病中的作用.方法:应用免疫组化PV法对10例对照者和32例先天性巨结肠患儿肠标本ICCs、SY进行检测.结果:在对照组及巨结肠有神经节细胞段,ICCs大量分布在肌层内及肌间神经丛周围,并形成网络结构.肌间神经丛、纵肌层、环肌层、黏膜肌层均可见大量SY免疫反应阳性产物.在无神经节细胞段,肠壁各层ICCs细胞密度明显减少甚至消失,正常所见的网络结构遭到破坏.肌间神经丛、黏膜下、环肌层、纵肌层SY表达均不同程度地减少.结论:ICCs、SY分布异常是先天性巨结肠病理改变之一,可能是该病重要的发病机制,参与肠运动障碍的发生.
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