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3zhong bu tong nong du de lv an tong he fen tai ni yong yu jing mai zhen tong de bi jiao
Author(s): 
Pages: 2430-2431
Year: Issue:  20
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  镇痛氯胺酮芬太尼;
Abstract: 目的:探讨氯胺酮在病人自控静脉镇痛(PCIA)中的临床应用.方法:选择骨科手术病人120例,随机分成4组,每组30例.K1组,0.1%氯胺酮+咪唑安定10mg;K2组,0.2%氯胺酮+咪唑安定10mg;K3组0.3%氯胺酮+咪唑安定10mg;F组,0.1%芬太尼+咪唑安定10mg.应用病人自控镇痛(PCA)泵LCP给药模式设置;总量100mL,负荷量4 mL,背景输注2 mL/h,PCA 2 mL,锁定时间30min.手术后感觉疼痛明显时(VAS 50mm左右)启动PCA泵.观察PCIA开始2、4、8、12、16、24、36、48 h各时间点的镇痛效果和不良反应.结果:镇痛效果K1组较F组差,K2组与F组相当,K3组优于F组(P<0.05).K1、K2、K3组间不良反应差异无显著性,仅个别出现轻微的幻觉或恶心呕吐,且明显少于F组(P<0.01).结论:0.3%的氯胺酮为合适镇痛浓度,可有效安全地用于骨科手术术后PCIA的镇痛治疗.
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