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Correlation between Absorption in Vivo and Dissolution in Vitro of Extended-Release Ciprofloxacin Hydrochloride Tablet
Author(s): 
Pages: 649-652
Year: Issue:  11
Journal: WORLD CLINICAL DRUGS

Keyword:  环丙沙星缓释制剂药物相互作用;
Abstract: 目的 对盐酸环丙沙星缓释片体外释放与体内吸收的相关性进行研究.方法 体外释放采用中国药典2000年版二部的转篮法,体内血药浓度以RP-HPLC法测定,以DAS软件计算药动学参数.结果 在12h平均累积释放99%,20例男性健康志愿者口服单剂量500mg盐酸环丙沙星缓释片的体内过程符合开放一室模型.结论 将体外释放百分率即释放度(F)对体内吸收分数(f)回归得回归方程为:f=-0.51853+1.14322 F,对相关系数进行检验,两者之间存在显著相关性(P<0.05).
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