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Comparison of intermittent versus continuous androgen blockade in the treatment of advanced prostate cancer
Author(s): 
Pages: 761-764
Year: Issue:  11
Journal: CHINESE JOURNAL OF UROLOGY

Keyword:  前列腺肿瘤间歇性雄激素阻断持续性雄激素阻断去势副反应;
Abstract: 目的 比较间歇性与持续性雄激素阻断治疗晚期前列腺癌的疗效和副反应. 方法晚期前列腺癌患者69例,分2组.A组34例行间歇性联合雄激素阻断治疗,B组35例行手术去势加抗雄激素药物即持续性雄激素阻断治疗.比较2组患者的疾病进展时间和副反应发生率.结果 A组中位随访31.5(10~60)个月,B组32.6(12~63)个月.A组患者共行60个周期治疗,平均治疗周期13.7个月,其中治疗期6.4个月、间歇期7.3个月.A、B组中位疾病进展时间分别为31、28个月,差异无统计学意义(P=0.446);骨转移患者中A组中位疾病进展时间24个月,B组为18个月,2组比较差异有统计学意义(P=0.04).2组副反应发生率分别为:潮热症状A组20.6%(7/34),B组62.9%(22/35)(P<0.01);骨质疏松A组11.8%(4/34),B组31.4%(11/35)(P<0.05);乳房肿痛A组14.7%(5/34),B组37.1%(13/35)(P<0.05). 结论对晚期前列腺癌患者行雄激素阻断治疗应首选间歇性联合雄激素阻断治疗.
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