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Issue:
The Research Progress on Avian Influenza Virus Nonstructure Protein
Author(s):
ZHAO Feng-ju
,
LI Jing-chun
,
ZHAO Yu-jun
Pages:
15
-
17
Year:
2006
Issue:
9
Journal:
JILIN ANIMAL SCIENCE AND VETERINARY MEDICINE
Keyword:
禽流感病毒
;
非结构蛋白
;
研究进展
;
Abstract:
流感病毒含8个负链单股独立的RNA片段,共编码10种蛋白.每种蛋白具有不同的结构和功能.其中NS基因合成NS1和NS2两种蛋白质,NS1为非结构蛋白,NS2为结构蛋白,这两种蛋白质大量存在于感染的细胞中.NS1蛋白在病毒转录及感染过程中起重要作用,与禽流感病毒的致病性密切相关,其主要功能是以多种方式解除宿主干扰素防御系统.随着分子生物技术的快速发展,关于NS1蛋白在禽流感病毒致病性方面的作用的研究也取得了一定的进展.文章主要对流感病毒NS基因的特点及其编码蛋白质功能进行综述.
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