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Protective effect of Uncaria rhynchophylla total alkaloids pretreatment on hippocampal neurons after acute hypoxia
Author(s): 
Pages: 763-765
Year: Issue:  9
Journal: CHINA JOURNAL OF CHINESE MATERIA MEDICA

Keyword:  钩藤缺氧海马神经元膜片钳;
Abstract: 目的:观察钩藤总碱预处理对急性缺氧后海马神经元电压门控性Na+电流的影响.方法:原代培养大鼠海马神经元,分为常氧、急性缺氧和钩藤总碱预处理进行实验.采用膜片钳全细胞记录技术,检测海马神经元钠电流(INa)的变化.结果:急性缺氧后,细胞INa幅度明显降低,INa阈值右移;而经钩藤总碱预处理的海马神经元INa的降低幅度明显减轻.结论:钩藤总碱预处理提高了海马神经元对急性缺氧的耐受性,对神经元有显著保护作用.
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