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Meta-analysis of effectiveness and safety of intravenous pantoprazple for treating upper gastrointestinal hemorrhage
Author(s): 
Pages: 497-499
Year: Issue:  7
Journal: ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL

Keyword:  泮托拉唑上消化道出血安全性有效性meta分析;
Abstract: 目的了解注射用泮托拉唑治疗上消化道出血的有效性和安全性差异.方法应用meta分析对19篇文献注射用泮托拉唑与其他抑制胃酸药物治疗上消化道出血的21项有效性研究和16项安全性研究进行同质性检验和合并效应量的估计.结果 (1)同质性检验:有效性,χ2=14.6717,自由度为20;安全性,χ2=8.7235,自由度为15,两者P均大于0.05,具有同质性,可以合并结果.(2)合并效应量的估计:有效性,OR合并=3.5495,OR合并95%的可信区间为2.6219~4.8053.OR合并的检验:χ2=67.1900,P<0.001;安全性,OR合并=0.4812,OR合并95%的可信区间为0.3191~0.7266.OR合并的检验:χ2=12.1781,P<0.001.结论注射用泮托拉唑治疗上消化道出血的疗效总体优于对照组,且副作用较低.
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