Assessment of simvastatin with a self-emulsifying capsule in vivo
Author(s): TIAN Da-feng, LI Ying, MO Feng-kui, YU Hong-kai, WANG Zhong-yan
Pages: 27-28,26
Year: 2006 Issue: 7
Journal: PROGRESS IN MODERN BIOMEDICINE
Keyword: 辛伐他汀; 自微乳化; 胶囊; HPLC; 生物利用度;
Abstract: 目的:研究辛伐他汀(SV)自微乳化胶囊在比格犬体内的药代动力学.方法:采用HPLC法测定比格犬血浆药物浓度,与市售片比较,考察SV自微乳化胶囊的体内药代动力学.结果:药代动力学测定结果表明:与市售片比较,自微乳化胶囊血药浓度达峰时间提前、最高血药浓度增大,Tmax=1.41h,Cmax=46.22ng·Ml-1,而市售片的Tmax=2.65h,Cmax=12.43ng·mL-1;AUC0-∞为市售片剂的227.5%.结论:自微乳化胶囊可以显著提高SV的体内吸收.
Pages: 27-28,26
Year: 2006 Issue: 7
Journal: PROGRESS IN MODERN BIOMEDICINE
Keyword: 辛伐他汀; 自微乳化; 胶囊; HPLC; 生物利用度;
Abstract: 目的:研究辛伐他汀(SV)自微乳化胶囊在比格犬体内的药代动力学.方法:采用HPLC法测定比格犬血浆药物浓度,与市售片比较,考察SV自微乳化胶囊的体内药代动力学.结果:药代动力学测定结果表明:与市售片比较,自微乳化胶囊血药浓度达峰时间提前、最高血药浓度增大,Tmax=1.41h,Cmax=46.22ng·Ml-1,而市售片的Tmax=2.65h,Cmax=12.43ng·mL-1;AUC0-∞为市售片剂的227.5%.结论:自微乳化胶囊可以显著提高SV的体内吸收.
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