The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit
later.
We apologize for any inconvenience caused
A Modified Rat Model of Dilated Cardiomyopathy Induced by Adriamycin
Author(s): LI Shu-guo, MAO Xiao-bo, ZHANG Feng, SUN Zheng-xiong, ZENG Qiu-tang
Pages: 415-
418
Year: 2006
Issue:
7
Journal: CHINESE JOURNAL OF COMPARATIVE MEDICINE
Keyword: 阿霉素; 心力衰竭; 模型; 动物; 大鼠;
Abstract: 目的建立阿霉素心肌病(Adr-DCM)动物模型,并对其进行评价.方法Adr-DCM模型建立方法:阿霉素2 mg/kg,腹腔注射,前5次为每3天注射,后5次每7天注射,累计用量为20 mg/kg.应用超声心动图检测心功能指标,电子显微镜评价心肌超微结构.结果阿霉素应用4周后即存在心肌超微结构改变,10周后大鼠心力衰竭诱导成功率100%,死亡率25%.结论阿霉素多次腹腔注射可以导致大鼠心肌重构和心功能异常,通过改良给药方法,动物死亡率明显降低,可以作为心肌病模型制作的新方法推广.
Citations
No citation found