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A Modified Rat Model of Dilated Cardiomyopathy Induced by Adriamycin
Author(s): 
Pages: 415-418
Year: Issue:  7
Journal: CHINESE JOURNAL OF COMPARATIVE MEDICINE

Keyword:  阿霉素心力衰竭模型动物大鼠;
Abstract: 目的建立阿霉素心肌病(Adr-DCM)动物模型,并对其进行评价.方法Adr-DCM模型建立方法:阿霉素2 mg/kg,腹腔注射,前5次为每3天注射,后5次每7天注射,累计用量为20 mg/kg.应用超声心动图检测心功能指标,电子显微镜评价心肌超微结构.结果阿霉素应用4周后即存在心肌超微结构改变,10周后大鼠心力衰竭诱导成功率100%,死亡率25%.结论阿霉素多次腹腔注射可以导致大鼠心肌重构和心功能异常,通过改良给药方法,动物死亡率明显降低,可以作为心肌病模型制作的新方法推广.
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