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Study on antiviral effect of compound of ulmus macrocarpa on herpes simplex virus- Ⅰ in vitro
Author(s): 
Pages: 27-30
Year: Issue:  6
Journal: ACTA CHINESE MEDICINE AND PHARMACOLOGY

Keyword:  复方芜荑Ⅰ型单纯疱疹病毒细胞病变四甲基偶氮唑蓝;
Abstract: 目的:探讨复方芜荑水和醇提取物体外抗Ⅰ型单纯疱疹病毒(Herpes Simplex Virus-Ⅰ,HSV-Ⅰ)的活性.方法:运用细胞病变法(CPE)及MTT染色法观察复方芜荑水和醇提取物体外对HSV-Ⅰ所致细胞病变的抑制作用、感染的预防作用和对HSV-Ⅰ的直接杀伤作用.结果:复方芜荑水和醇提取物体外有抑制HSV-Ⅰ所致CPE的作用,并且可持续抑制.31.25 mg/ml复方芜荑水提物作用24h和72h后对细胞病变的抑制率分别为69.69%和69.79%;15.625 mg/ml醇提物作用24h和72h后对细胞病变的抑制率分别为50.26%和52.73%.其水提物效果优于醇提物,但两者对于HSV-Ⅰ的直接杀伤作用和感染的预防作用均较弱.结论:复方芜荑体水和醇提取物外有抗HSV-Ⅰ的活性.
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