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Effect of Qixuan Yixin Capsule on mRNA expression of HGF in acute ischemia myocardium of diabetic rats
Author(s): 
Pages: 34-36
Year: Issue:  6
Journal: ACTA CHINESE MEDICINE AND PHARMACOLOGY

Keyword:  芪玄益心胶囊糖尿病动物模型肝细胞生长因子大鼠;
Abstract: 目的:探讨芪玄益心胶囊对糖尿病(DM)大鼠急性缺血心肌保护的作用机制.方法:以四氧嘧啶腹腔注射致胰腺损伤,舌下静脉注射垂体后叶素致心肌急性缺血复制大鼠DM心肌缺血模型,将其随机分为美吡达组,丹参滴丸组,芪玄益心胶囊高、中、低剂量组,模型组,并设空白对照组.观察各组模型心肌组织HGFmRNA水平的表达并与空白组对照.结果:模型组及各治疗组与空白组比较,HGFmRNA表达均显著增高(P<0.01).芪玄益心胶囊各剂量组与模型组比较,HGFmRNA表达明显增高(P<0.01),以高剂量组变化最显著.芪玄益心胶囊与美吡达、丹参滴丸比较,对心肌组织HGFmRNA改善优于美吡达组(P<0.01),而高剂量组则优于丹参滴丸组(P<0.05).结论:芪玄益心胶囊可能通过增强HGFmRNA表达,对心肌产生积极的保护作用.
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