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Issue:
Protective effects of parasites infection on autoimmune diseases
Author(s):
YANG Xiao-lei
,
LIU Wen-qi
Pages:
264
-
268
Year:
2006
Issue:
5
Journal:
INTERNATIONAL JOURNAL OF MEDICAL PARASITIC DISEASES
Keyword:
寄生虫感染
;
自身免疫性疾病
;
Th1/Th2
;
Abstract:
流行病学调查表明在许多国家寄生虫感染率和自身免疫性疾病的发病率往往呈负相关,提示寄生虫感染对自身免疫性疾病可能有保护作用.早期的研究表明,Th1/Th2细胞活性的相对平衡对机体局部和全身的免疫及病理状况都有直接影响.自身免疫性疾病往往伴随着Th1细胞的过度活动;而蠕虫感染却常可诱导一个偏向于Th3细胞的反应.综合以上事实,有理由推测,某些寄生虫感染对某些自身免疫性疾病可能有一定的保护作用.
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