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IRF Family and Immune Regulation
Author(s):
CAO Yong-Hao
,
ZHANG Shi-Jian
,
ZHOU Yuan-Cong
Pages:
387
-
389
Year:
2006
Issue:
5
Journal:
CHEMISTRY OF LIFE
Keyword:
干扰素
;
干扰素调节因子
;
免疫调控
;
Toll样受体
;
造血干细胞
;
Abstract:
干扰素(IFN)是一类能够抵抗病毒感染、抑制细胞周期和行使免疫调节功能的细胞因子.干扰素调节因子家族(IRF)成员因在病毒感染时能够结合到IFN启动子上诱导、调节IFN的表达而得名.最近的研究表明:IRF是一类多功能的转录因子,在干扰素转录调控,病原体免疫反应,细胞因子信号转导,细胞增殖调控;以及造血干细胞的发育、淋巴细胞的分化,自稳平衡,先天性免疫和适应性免疫调控等方面都有着重要的作用.IRF的功能及其分子机制的揭示将对抗病毒,免疫疾病和恶性肿瘤的治疗提供新的靶向策略.
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