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Plasma level of IGF-1 and VEGF in patients with diabetic foot
Author(s):
TANG Xue-fu
,
SUN Jin-song
,
LI Hong-hui
,
HE Qin
,
KE Xin-qiao
Pages:
22
-
23
Year:
2006
Issue:
5
Journal:
CHINESE JOURNAL OF BIRTH HEALTH AND HEREDITY
Keyword:
糖尿病足
;
胰岛素样生长因子-1
;
血管内皮生长因子
;
Abstract:
目的研究糖尿病足患者血清IGF-1和VEGF水平与糖尿病足部溃疡或坏疽的关系.方法分别采用放射免疫分析法和定量双抗体夹心ELISA法检测23例糖尿病足患者血清IGF-1和VEGF水平,并与健康人和2型糖尿病患者进行比较.结果糖尿病足患者血清IGF-1和VEGF水平显著低于糖尿病患者和健康对照组(P<0.05).结论生长因子IGF-1和VEGF是糖尿病足发生和发展的重要影响因素,IGF-1和VEGF水平低下可能是糖尿病足部溃疡经久不愈的重要原因.
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