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Role of Plasma Motilin and Calcitonin Gene -related Peptide on Gastric Motility Abnormalities in Patients with Liver Cirrhosis
Author(s): 
Pages: 21-24
Year: Issue:  4
Journal: JOURNAL OF HUBEI INSTITUTE FOR NATIONALITIES(MEDICAL EDITION)

Keyword:  肝硬化胃电图胃排空胃动素降钙素基因相关肽;
Abstract: 目的 探讨肝硬化患者胃排空和胃电图参数与胃肠激素的关系.方法 对48例肝硬化患者进行餐前餐后胃电图检测,B超测定胃液体排空功能,用放免法测定血浆胃动素和降钙素基因相关肽水平;根据肝功能Child-Pugh A、B、C分级将肝硬化患者分为3个亚组;18例健康自愿者作为对照组.结果 与健康对照组相比,肝硬化患者餐前餐后胃电图的主功率、功率比和正常慢波节律均显著降低(P值均<0.01);胃电图节律紊乱明显增加(P值均<0.01);胃半排空时间明显延长(P<0.01);血浆胃动素和降钙素基因相关肽明显升高(P值均<0.01).随着肝功能Child-Pugh A、B、C分级,肝硬化患者上述变化越来越明显(P值均<0.05).胃电图参数与胃半排空时间有显著相关性(P值均<0.05);胃电图参数分别与血浆胃动素和降钙素基因相关肽也有显著相关性(P值均<0.05).结论 肝硬化患者胃排空功能延迟可能与胃电节律紊乱,以及血浆胃动素和降钙素基因相关肽水平异常有关.
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