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Effects of ganoderma spores on CDK4 expression in preventing embryonic neural tube defects induced by retinoic acid in pregnant mice
Author(s): ZHANG Wei, ZENG Yuan-shan, XIONG Yi, TANG Jiu-yu, CHEN Sui-jun, ZHONG Zhi-qiang
Pages: 251-
253,封二
Year: 2006
Issue:
4
Journal: ANATOMY RESEARCH
Keyword: 灵芝孢子; 维甲酸; 神经管畸形; 依赖细胞周期蛋白激酶4; 胚胎; 小鼠;
Abstract: 目的 探讨预先服用灵芝孢子在降低维甲酸诱导胚胎小鼠发生神经管畸形过程中对依赖细胞周期蛋白激酶4(cyclin dependent protein kinase 4,Cdk4)表达的影响.方法 于孕期小鼠E0d时给予灵芝孢子组的孕鼠胃饲灵芝孢子溶液,8 g·kg-1·d-1.实验对照组的孕鼠胃饲等量溶剂.于E7.75d时,两组孕鼠一次性胃饲维甲酸,剂量为50 mg/kg体重.正常对照组孕鼠胃饲等量灵芝孢子溶剂,但是在E7.75d时,仅给予维甲酸溶剂.空白对照组孕鼠常规饲养不作任何处理.在孕期E10.5d时取出4组孕鼠的胚胎,应用免疫荧光组织化学染色和Western blot检测胚胎神经管神经上皮Cdk4表达情况.结果 实验对照组孕鼠胚胎神经管神经上皮细胞Cdk4的表达明显降低,而灵芝孢子组胚胎表达Cdk4的强度明显高于实验对照组.正常对照组与空白对照组相比Cdk4的表达无统计学意义(P>0.05).结论 灵芝孢子可能是通过增强神经管神经上皮细胞表达Cdk4降低维甲酸诱导胚胎小鼠神经管畸形的发生.
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