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The effect Effect of Total Alkaloids from Solanum nigrum on activities Activities of Na+,K+-ATPase and Ca++,Mg++-ATPase in tumor Tumor cell Cell membranceMembrance
Author(s): 
Pages: 40-43
Year: Issue:  4
Journal: WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE AND MATERIA MEDICA

Keyword:  龙葵总碱肿瘤细胞膜钠泵钙泵;
Abstract: 目的: 观察龙葵总碱对S180小鼠及H22小鼠肿瘤细胞膜Na+,K+-ATPase及Ca++,Mg++-ATPase活性的影响.方法:荷瘤小鼠分为治疗组(高剂量、中剂量、低剂量)和对照组(生理盐水组、环磷酰胺组),分别测定各组肿瘤细胞膜的Na+,K+-ATPase及Ca++,Mg++-ATPase活性.结果:龙葵总碱对S180小鼠及H22小鼠肿瘤细胞膜Na+,K+-ATPase及Ca++,Mg++-ATPase活性均有明显的抑制作用,并且其抑制作用呈量效正相关.结论:龙葵总碱这一作用可能是其抗肿瘤作用机理之一.
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