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In vitro Eexperimental Sstudy on Aanti- Oophoromamalignant tumor of ovary Eeffect of Fuzheng Xiaoliu Particles (Granula 扶正消瘤颗粒)
Author(s): 
Pages: 44-48
Year: Issue:  4
Journal: WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE AND MATERIA MEDICA

Keyword:  扶正消瘤颗粒卵巢癌血清药理学细胞凋亡;
Abstract: 目的:阐述扶正消瘤颗粒(CM)在体外的抗肿瘤作用.方法:制备含药血清,作用于体外培养的肿瘤细胞系SKOV-3,分为空白组(control)、CM组、顺铂组(DDP)和CM+DDP组,采用MTT法检测其量效关系和时效关系,用TUNEL、透射电镜和流式细胞术(FCM)检测细胞凋亡的发生,用Westerblot检测PCNA、bcl-2和bax的表达.结果:MMT显示本方有一定量效关系和时效关系,浓度愈大,作用时间愈长,效果愈明显;TUNEL和透射电镜及FCM均提示了细胞凋亡的发生,而Westernblot的结果则显示了细胞凋亡的发生与bcl-2/bax比率的下调有关,使细胞增殖受到抑制.结论:扶正消瘤颗粒在体外有一定的抗肿瘤作用,并有增效之功.
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