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Effects of Kangfengshi Granules on expressions of osteoprotegerin, RANKL and M-CSF in bone tissues of rats with collagen-induced arthritis
Author(s): Yi-Heng LIU, Hai-Ying ZHANG, Hong-Min ZANG, Jun-Chang CHENG, Yan-Min LI
Pages: 307-
310
Year: 2006
Issue:
3
Journal: JOURNAL OF CHINESE INTEGRATIVE MEDICINE
Keyword: 抗风湿颗粒; 关节炎; 骨保护素; 核因子-κB受体激活因子配体; 巨噬细胞集落刺激因子;
Abstract: 目的:观察抗风湿颗粒(Kangfengshi Granules,KFSG)对胶原诱导关节炎大鼠骨组织中骨保护素(osteoprotegerin,OPG)、核因子-κB受体激活因子配体(receptor activator of nuclear factor-κB ligand,RANKL)和巨噬细胞集落刺激因子(macrophage colony stimulating factor,M-CSF)mRNA表达的影响,探讨KFSG治疗类风湿关节炎(rheumatoid arthritis,RA)的作用机制.方法:40只SD大鼠随机分为正常对照组、模型组、环孢菌素A(cyclosporine A,CsA)治疗组和KFSG治疗组.除正常对照组外,其余各组大鼠予以皮下注射Ⅱ型胶原诱导关节炎模型.治疗4周后,采用实时定量PCR技术检测各组大鼠骨组织中OPG、RANKL和M-CSF mRNA的表达水平.结果:造模大鼠90%出现关节炎症状.治疗4周后,模型组、CsA治疗组和KFSG治疗组与正常对照组比较,RANKL mRNA和M-CSF mRNA的表达增高,OPGmRNA的表达降低,RANKL mRNA/OPG mRNA比值亦增高,差异均有统计学意义.KFSG治疗组与模型组比较,OPG mRNA的表达水平上调,M-CSF mRNA的表达水平下调,RANKL mRNA/OPG mRNA比值下降,差异均有统计学意义.结论:KFSG治疗RA骨质破坏的分子机制可能与其上调OPG mRNA的表达、下调M-CSF mRNA的表达及降低RANKL mRNA/OPG mRNA比值有关.
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