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The Expression of GFAP after Brain Concussion in Rats
Author(s): 
Pages: 88-89,92
Year: Issue:  2
Journal: JOURNAL OF FORENSIC MEDICINE

Keyword:  脑震荡胶质纤维酸性蛋白(GFAP)免疫组织化学损伤时间;
Abstract: 目的探讨脑震荡后GFAP在脑内的时间性变化规律,为脑震荡后经过时间的法医学鉴定提供理论依据.方法54只SD大鼠按不同损伤时间分成3,6,12,24h和2,4,7,10d及对照组,用单摆式机械打击装置建立大鼠脑震荡模型,用免疫组织化学技术观察大鼠脑震荡后GFAP在伤后不同时间的表达情况.结果正常大鼠可见少量GFAP阳性细胞,脑震荡后6h后,随伤后经过时间的延长,GFAP表达逐渐增强,阳性细胞数目增多,胞体增大,突起增粗、增多,染色加深,至伤后7 d达高峰.结论 GFAP的检测可作为法医病理学诊断脑震荡的依据和推断脑震荡后经过时间的参考指标.
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