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SIPAR EXPRESSION PATTERN DURING THE DEVELOPMENT OF MOUSE EMBRYO DETECTED BY WHOLE MOUNT IN SITU HYBRIDIZATION
Author(s): 
Pages: 121-124
Year: Issue:  2
Journal: ACTA ANATOMICA SINICA

Keyword:  SIPAR胚胎发育原位杂交小鼠;
Abstract: 目的检测对STAT3信号通路有调节作用的新基因SIPAR(STAT3 interacting protein as a represor)在小鼠胚胎发育过程中不同阶段的表达.方法采用地高辛标记探针的整体胚胎原位杂交方法.结果 SIPAR在dpc9.5的小鼠胚胎眼泡和听泡中有明显的表达,在dpc9.5~12.5的小鼠胚胎脊柱神经和脑部中枢神经都有表达,在dpc12.5小鼠胚胎脑、眼泡和脊柱中表达增强.结论 SIPAR主要集中表达在小鼠胚胎的神经系统,SIPAR可能与神经系统发育相关.
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