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Experimental Study of Xuefu Zhuyu Decoction on Model of Migraine
Author(s): 
Pages: 13-14
Year: Issue:  2
Journal: JOURNAL OF SHANXI COLLEGE OF TRADITIONAL CHINESE MEDICINE

Keyword:  血府逐瘀汤偏头痛小鼠;
Abstract: 目的:观察血府逐瘀汤对偏头痛小鼠的作用.方法:昆明种小鼠72只,随机分为6组,每组12只.第1组为正常对照组,不做皮下注射;第2组为假手术组,皮下注射等体积的0.9%氯化钠注射液;第3~6组制成偏头痛模型组(小鼠皮下注射利血平10 mg/kg,14 d)后,第1~3组给予等容积的蒸馏水,第4~6组分别给予血府逐瘀汤7.6 g/kg、15.2 g/kg、22.8 g/kg.采用热板法测痛阈,取血测凝血时间,取脑匀浆测五羟色胺(5-HT).结果:血府逐瘀汤能延长凝血时间,提高痛阈,调节5-HT的过度降低.结论:血府逐瘀汤能治疗利血平所致小鼠偏头痛.
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