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Issue:
The anticancer effects of carotenoids and gene expression
Author(s):
ZHAO Wen-'en
,
KANG Bao-shan
,
JIAO Feng-yun
,
ZHANG Ruan-ai
Pages:
1
-
6
Year:
2006
Issue:
2
Journal:
JOURNAL OF BIOLOGY
Keyword:
类胡萝卜素
;
抗癌作用
;
基因表达
;
Abstract:
类胡萝卜素是通过干扰癌细胞生长或细胞死亡的有关途径显示其抗癌作用的,包括细胞增殖、生长因子的信号传输、细胞间隙连接通讯、细胞分化及凋亡.类胡萝卜素引起参与这些过程的调节蛋白质表达发生改变.已发现几个转录系统在其抗癌活性中起作用,如类视黄素受体、过氧化物酶体激活受体(PPAR)、抗氧化剂应答元件(ARE)、异生素受体及激活剂蛋白-1(AP-1),它们构成各种类胡萝卜素与其它微量营养素协同抗癌作用的基础.
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