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Effects of puerarin on the expression of GAD67mRNA after experimental cerebral ischemic damage in rats
Author(s): QI Zhong-hua, LIU Qun
Pages: 207-
209
Year: 2006
Issue:
2
Journal: JOURNAL OF APOPLEXY AND NERVOUS DISEASES
Keyword: 脑缺血; 谷氨酸脱羧酶; 葛根素;
Abstract: 目的观察葛根素对实验性脑缺血谷氨酸脱羧酶(GAD67)表达变化的影响.方法应用原位杂交方法检测大鼠永久大脑中动脉闭塞(MCAO)模型GAD67mRNA在脑缺血后不同时间的表达.结果正常组及假手术组GAD67mRNA在脑组织中表达较弱.对照组和治疗组GAD67mRNA在脑缺血后6h即开始表达增强,在72h达高峰,后逐渐下降,GAD67mRNA表达至第2周仍高于正常,治疗组GAD67mRNA表达高于对照组.结论葛根素可以促进实验性脑缺血后GAD67mRNA的表达,具有神经保护作用,有助于神经功能的恢复.
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