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Clinical research of vascular endothelial growth factor expression in patients with malignant tumor
Author(s): 
Pages: 76-79
Year: Issue:  1
Journal: JOURNAL OF INTERNATIONAL ONCOLOGY

Keyword:  内皮生长因子新生血管化病理性恶性肿瘤恶性渗出液;
Abstract: 目的通过测定血管内皮生长因子(VEGF)在肿瘤患者血清及恶性渗出液中的含量,以明确VEGF能否作为肿瘤标志物.方法通过酶联免疫吸附法测定VEGF在健康人、肿瘤患者血清及恶性渗出液中的含量.结果恶性肿瘤患者血清中VEGF含量较健康组高,且有显著差异(P<O.01),但多数肿瘤转移与非转移组比较无差异(肝癌患者除外),非转移性胃肠道肿瘤患者血清中VEGF与CEA、CA19-9有相关性,其他恶性肿瘤血清中VEGF与CEA、CA19-9均无相关性.22例肺癌患者渗出液中VEGF中位数229.2pg/ml,比其血清中VEGF中位数高(62.2pg/ml).有恶性渗出液患者血清中VEGF与其渗出液中VEGF无相关性,渗出液中VEGF与其CEA、CA19-9及LDH亦无相关性.肺癌患者经治疗血清中VEGF随病情好转而下降,也可随病情进展而升高.结论①恶性肿瘤患者血清中VEGF水平比健康人高.②VEGF可作为一个非特异性的肿瘤标志物,且与治疗疗效呈正相关.
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